In Vivo Acquisition of a Plasmid-Mediated bla KPC-2 Gene among Clonal Isolates of Serratia marcescens

Three patients admitted to a Greek hospital were infected with Serratia marcescens isolates that exhibited reduced susceptibility to carbapenems and harbored Klebsiella pneumoniae carbapenemase (KPC) enzymes. In two of these cases, the patients were initially infected by carbapenem-susceptible S. ma...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical microbiology 2010-07, Vol.48 (7), p.2546-2549
Main Authors: Tsakris, Athanassios, Voulgari, Evangelia, Poulou, Aggeliki, Kimouli, Maria, Pournaras, Spyros, Ranellou, Kyriaki, Kosmopoulou, Olga, Petropoulou, Dimitra
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Three patients admitted to a Greek hospital were infected with Serratia marcescens isolates that exhibited reduced susceptibility to carbapenems and harbored Klebsiella pneumoniae carbapenemase (KPC) enzymes. In two of these cases, the patients were initially infected by carbapenem-susceptible S. marcescens isolates. Molecular typing and plasmid analysis suggested that all three patients had clonally indistinguishable isolates of S. marcescens that acquired a plasmid-mediated bla KPC-2 gene during the hospitalization.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00264-10