Prevalence and Sequence Diversity of a Factor Required for Actin-Based Motility in Natural Populations of Burkholderia Species

Actin-based motility of the melioidosis pathogen Burkholderia pseudomallei requires BimA. We report a high degree of conservation of bimA in 99 B. pseudomallei isolates from the area of endemicity. A geographically restricted subset of B. pseudomallei isolates harbored a B. mallei-like bimA allele (...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2008-07, Vol.46 (7), p.2418-2422
Main Authors: Sitthidet, Chayada, Stevens, Joanne M, Chantratita, Narisara, Currie, Bart J, Peacock, Sharon J, Korbsrisate, Sunee, Stevens, Mark P
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Bacteriology
Biological and medical sciences
Burkholderia mallei - genetics
Burkholderia pseudomallei
Burkholderia pseudomallei - genetics
Burkholderia pseudomallei - isolation & purification
DNA, Bacterial - genetics
Endemic Diseases
Fundamental and applied biological sciences. Psychology
Humans
Locomotion
Melioidosis - epidemiology
Melioidosis - microbiology
Microbiology
Microfilament Proteins - genetics
Miscellaneous
Molecular Sequence Data
Polymorphism, Genetic
Sequence Alignment
Sequence Analysis, DNA
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Summary:Actin-based motility of the melioidosis pathogen Burkholderia pseudomallei requires BimA. We report a high degree of conservation of bimA in 99 B. pseudomallei isolates from the area of endemicity. A geographically restricted subset of B. pseudomallei isolates harbored a B. mallei-like bimA allele (12.1%), confounding a differential diagnostic test based on amplification of species-specific bimA regions.
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/JCM.00368-08