Comprehensive Analysis of a Norovirus-Associated Gastroenteritis Outbreak, from the Environment to the Consumer

Noroviruses have been recognized to be the predominant agents of nonbacterial gastroenteritis outbreaks in humans, and their transmission via contaminated shellfish consumption has been demonstrated. Norovirus laboratory experiments, volunteer challenge studies, and community gastroenteritis outbrea...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2010-03, Vol.48 (3), p.915-920
Main Authors: Le Guyader, Françoise S, Krol, Joanna, Ambert-Balay, Katia, Ruvoen-Clouet, Nathalie, Desaubliaux, Benedicte, Parnaudeau, Sylvain, Le Saux, Jean-Claude, Ponge, Agnès, Pothier, Pierre, Atmar, Robert L, Le Pendu, Jacques
Format: Article
Language:English
Subjects:
Adult
Animals
Biological and medical sciences
Blood Group Antigens
Blood Group Antigens - analysis
Caliciviridae Infections
Caliciviridae Infections - epidemiology
Caliciviridae Infections - virology
Disease Outbreaks
Epidemiology
Feces
Feces - virology
Foodborne Diseases
Foodborne Diseases - epidemiology
Foodborne Diseases - virology
France
France - epidemiology
Fundamental and applied biological sciences. Psychology
Gastroenteritis
Gastroenteritis - epidemiology
Gastroenteritis - virology
Humans
Life Sciences
Microbiology
Microbiology and Parasitology
Middle Aged
Miscellaneous
Norovirus
Norovirus - isolation & purification
Ostreidae
Ostreidae - virology
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
RNA, Viral - genetics
Saliva
Saliva - chemistry
Virology
Young Adult
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Summary:Noroviruses have been recognized to be the predominant agents of nonbacterial gastroenteritis outbreaks in humans, and their transmission via contaminated shellfish consumption has been demonstrated. Norovirus laboratory experiments, volunteer challenge studies, and community gastroenteritis outbreak investigations have identified human genetic susceptibility factors related to histo-blood group antigen expression. Following a banquet in Brittany, France, in February 2008, gastroenteritis cases were linked to oyster consumption. This study identified an association of the norovirus illnesses with histo-blood group expression, and oyster contamination with norovirus was confirmed by qualitative and quantitative analyses. The secretor phenotype was associated with illness, especially for the non-A subgroup. The study showed that, in addition to accidental climatic events that may lead to oyster contamination, illegal shellfish collection and trading are also risk factors associated with outbreaks.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01664-09