Cutaneous Infection Caused by Macrophomina phaseolina in a Child with Acute Myeloid Leukemia

We report a case of Macrophomina phaseolina skin infection in an immunocompromised child with acute myeloid leukemia, which was treated successfully with posaconazole without recurrence after a hematopoietic stem cell transplant. The fungus was identified by DNA sequencing using both the internal tr...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2009-06, Vol.47 (6), p.1969-1972
Main Authors: Srinivasan, Ashok, Wickes, Brian L, Romanelli, Anna M, Debelenko, Larisa, Rubnitz, Jeffrey E, Sutton, Deanna A, Thompson, Elizabeth H, Fothergill, Annette W, Rinaldi, Michael G, Hayden, Randall T, Shenep, Jerry L
Format: Article
Language:English
Subjects:
Antifungal Agents - therapeutic use
Ascomycota - isolation & purification
Biological and medical sciences
Case Reports
Child
Dermatomycoses - diagnosis
Dermatomycoses - drug therapy
Dermatomycoses - microbiology
DNA, Fungal - chemistry
DNA, Fungal - genetics
DNA, Ribosomal Spacer - chemistry
DNA, Ribosomal Spacer - genetics
Female
Fundamental and applied biological sciences. Psychology
Humans
Immunocompromised Host
Leukemia, Myeloid, Acute - complications
Macrophomina phaseolina
Microbiology
Miscellaneous
Molecular Sequence Data
Mycology
Sequence Analysis, DNA
Skin - pathology
Triazoles - therapeutic use
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Summary:We report a case of Macrophomina phaseolina skin infection in an immunocompromised child with acute myeloid leukemia, which was treated successfully with posaconazole without recurrence after a hematopoietic stem cell transplant. The fungus was identified by DNA sequencing using both the internal transcribed spacer and D1/D2 region of the 28S ribosomal DNA gene.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.02397-08