CD8 + T-Cell Epitope Mapping for Pneumonia Virus of Mice in H-2 b Mice

The paramyxovirus pneumonia virus of mice (PVM) is a rodent model of human respiratory syncytial virus (hRSV) pathogenesis. Here we characterized the PVM-specific CD8 + T-cell repertoire in susceptible C57BL/6 mice. In total, 15 PVM-specific CD8 + T-cell epitopes restricted by H-2D b and/or H-2K b w...

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Bibliographic Details
Published in:Journal of virology 2013-09, Vol.87 (17), p.9949-9952
Main Authors: Walsh, Kevin B., Sidney, John, Welch, Megan, Fremgen, Daniel M., Sette, Alessandro, Oldstone, Michael B. A.
Format: Article
Language:English
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Summary:The paramyxovirus pneumonia virus of mice (PVM) is a rodent model of human respiratory syncytial virus (hRSV) pathogenesis. Here we characterized the PVM-specific CD8 + T-cell repertoire in susceptible C57BL/6 mice. In total, 15 PVM-specific CD8 + T-cell epitopes restricted by H-2D b and/or H-2K b were identified. These data open the door for using widely profiled, genetically manipulated C57BL/6 mice to study the contribution of epitope-specific CD8 + T cells to PVM pathogenesis.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00339-13