Mamu-B 08 -Positive Macaques Control Simian Immunodeficiency Virus Replication

Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B * 08 by PCR and...

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Bibliographic Details
Published in:Journal of virology 2007-08, Vol.81 (16), p.8827-8832
Main Authors: Loffredo, John T., Maxwell, Jess, Qi, Ying, Glidden, Chrystal E., Borchardt, Gretta J., Soma, Taeko, Bean, Alex T., Beal, Dominic R., Wilson, Nancy A., Rehrauer, William M., Lifson, Jeffrey D., Carrington, Mary, Watkins, David I.
Format: Article
Language:English
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Summary:Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B * 08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIV mac 239-infected Indian rhesus macaques revealed that Mamu-B * 08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B * 08 positive compared to 3% of progressors ( P = 0.00001). Mamu-B * 08 was also associated with a 7.34-fold decrease in chronic phase viremia ( P = 0.002). Mamu-B * 08 -positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00895-07