Arp2/3 complex is involved in the effect of glutoxim and molixan on intracellular Ca2+ concentration in macrophages

The involvement of Arp2/3 complex, which causes actin filament branching, in the effect of drugs glutoxim and molixan on intracellular Ca 2+ concentration was investigated. Using Fura-2AM microfluorimetry it was shown for the first time that Arp2/3 complex inhibitor CK-0944666 almost completely prev...

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Bibliographic Details
Published in:Biophysics (Oxford) 2014-09, Vol.59 (5), p.736-740
Main Authors: Milenina, L. S., Krutetskaya, Z. I., Naumova, A. A., Krutetskaya, N. I., Butov, S. N., Antonov, V. G.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biophysics
Cell Biophysics
Physics
Physics and Astronomy
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Summary:The involvement of Arp2/3 complex, which causes actin filament branching, in the effect of drugs glutoxim and molixan on intracellular Ca 2+ concentration was investigated. Using Fura-2AM microfluorimetry it was shown for the first time that Arp2/3 complex inhibitor CK-0944666 almost completely prevents the increase in intracellular Ca 2+ concentration, induced by glutoxim or molixan in macrophages. The data suggest the involvement of Arp2/3 complex in the glutoxim and molixan effect on the Ca 2+ signaling processes in macrophages.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350914050170