Morphological and physiological properties of the micromycete Arthrobotrys longa, a producer of longolytin, a proteolytic complex with a thrombolytic effect

Production of proteinases with plasmin-like and plasminogen-activating activities by a micromycete Arthrobotrys longa 1 was studied. Polycyclic growth of the producer in submerged cultures was observed, with an endogenous rhythm of periods of intense microconidia formation alternating with the phase...

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Bibliographic Details
Published in:Microbiology (New York) 2016-03, Vol.85 (2), p.180-184
Main Authors: Sharkova, T. S., Kornienko, E. I., Osmolovskii, A. A., Kreier, V. G., Baranova, N. A., Egorov, N. S.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Experimental Articles
Life Sciences
Medical Microbiology
Microbiology
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Summary:Production of proteinases with plasmin-like and plasminogen-activating activities by a micromycete Arthrobotrys longa 1 was studied. Polycyclic growth of the producer in submerged cultures was observed, with an endogenous rhythm of periods of intense microconidia formation alternating with the phases of drastic increase in the content of producing mycelium. The highest plasmin-like and plasminogen-activating activities (up to 1000 and 500 cond. U/mL, respectively) were found to correlate with the polycyclic growth of the producer, coinciding with the stage of microconidia germination. Enhanced secretion of proteinases with plasmin-like and plasminogen-activating activity was found to be associated with increased specific growth rate of А. longa 1.
ISSN:0026-2617
1608-3237
DOI:10.1134/S0026261716020168