Morphological and physiological properties of the micromycete Arthrobotrys longa, a producer of longolytin, a proteolytic complex with a thrombolytic effect

Production of proteinases with plasmin-like and plasminogen-activating activities by a micromycete Arthrobotrys longa 1 was studied. Polycyclic growth of the producer in submerged cultures was observed, with an endogenous rhythm of periods of intense microconidia formation alternating with the phase...

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Published in:Microbiology (New York) 2016-03, Vol.85 (2), p.180-184
Main Authors: Sharkova, T. S., Kornienko, E. I., Osmolovskii, A. A., Kreier, V. G., Baranova, N. A., Egorov, N. S.
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description Production of proteinases with plasmin-like and plasminogen-activating activities by a micromycete Arthrobotrys longa 1 was studied. Polycyclic growth of the producer in submerged cultures was observed, with an endogenous rhythm of periods of intense microconidia formation alternating with the phases of drastic increase in the content of producing mycelium. The highest plasmin-like and plasminogen-activating activities (up to 1000 and 500 cond. U/mL, respectively) were found to correlate with the polycyclic growth of the producer, coinciding with the stage of microconidia germination. Enhanced secretion of proteinases with plasmin-like and plasminogen-activating activity was found to be associated with increased specific growth rate of А. longa 1.
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Life Sciences
Medical Microbiology
Microbiology
title Morphological and physiological properties of the micromycete Arthrobotrys longa, a producer of longolytin, a proteolytic complex with a thrombolytic effect
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