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Mixed-ligand platinum(IV) complexes with amino acids and adenine
Complexing in platinum(IV)-adenine-amino acid (α-alanine (Ala), lysine (Lys), or histidine (His)) systems was studied by pH titration. The stability constants of 1: 1: 1 complexes were determined. The stability of these mixed-ligand complexes changes in the following order: Lys < Ala < His. Re...
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| Published in: | Russian journal of inorganic chemistry 2008-11, Vol.53 (11), p.1741-1746 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
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| Summary: | Complexing in platinum(IV)-adenine-amino acid (α-alanine (Ala), lysine (Lys), or histidine (His)) systems was studied by pH titration. The stability constants of 1: 1: 1 complexes were determined. The stability of these mixed-ligand complexes changes in the following order: Lys < Ala < His. Reactions between aqueous solutions of H
2
PtCl
6
and amino acids produced the following coordination compounds: Pt(C
3
H
6
NO
2
)(C
5
H
5
N
5
)Cl
3
· 2H
2
O, or Pt(Ala
−
)(Ade)Cl
3
· 2H
2
O (
I
); Pt(C
5
H
5
N
5
)(C
6
H
14
N
2
O
2
)Cl
4
· 2H
2
O, or Pt(Ade)(Lys)Cl
4
· 2H
2
O (
II
); and Pt(C
5
H
5
N
5
)(C
6
H
9
N
3
O
2
)Cl
4
· 3H
2
O or Pt(Ade)(Hist)Cl
4
· 3H
2
O (
III
). These complexes were characterized by
13
C NMR, IR, and X-ray photoelectron spectroscopy. Alanine is complexed via both amino and carboxy groups; lysine, via α-amino group exclusively; and histidine, via the amino group and the N3 heterocyclic atom. Adenine in these complexes is monodentate due to the N7 heterocyclic atom. The adenine amino group is apparently H-bonded to a water oxygen atom. |
|---|---|
| ISSN: | 0036-0236 1531-8613 |
| DOI: | 10.1134/S0036023608110120 |