virulence factors of Mycobacterium tuberculosis: Genetic control, new conceptions

The problem of Mycobacterium tuberculosis virulence, together with drug resistance, is becoming key for the design of drugs with a new mechanism of action and the production of modern concepts and tuberculosis treatment schemes. The review describes gene complexes and their products, including mycol...

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Bibliographic Details
Published in:Russian journal of genetics 2014, Vol.50 (8), p.775-797
Main Authors: Prozorov, A. A, Fedorova, I. A, Bekker, O. B, Danilenko, V. N
Format: Article
Language:English
Subjects:
acids
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
drug resistance
genes
genomics
Human Genetics
mechanism of action
Microbial Genetics and Genomics
Mycobacterium tuberculosis
new drugs
post-translational modification
Reviews and Theoretical Articles
selection criteria
transcription (genetics)
tuberculosis
virulence
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Summary:The problem of Mycobacterium tuberculosis virulence, together with drug resistance, is becoming key for the design of drugs with a new mechanism of action and the production of modern concepts and tuberculosis treatment schemes. The review describes gene complexes and their products, including mycolic acids and global regulatory systems at the level of transcriptional, translational, and post-translational modification, etc. The criteria for selection of virulence/pathogenicity factors that might be used for comparative genomic analysis of strains differing in the degree of virulence were recommended. The experimental approaches and test systems for an adequate estimation of the virulence degree of different strains of M. tuberculosis were analyzed.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795414080055