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virulence factors of Mycobacterium tuberculosis: Genetic control, new conceptions
The problem of Mycobacterium tuberculosis virulence, together with drug resistance, is becoming key for the design of drugs with a new mechanism of action and the production of modern concepts and tuberculosis treatment schemes. The review describes gene complexes and their products, including mycol...
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| Published in: | Russian journal of genetics 2014, Vol.50 (8), p.775-797 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c312t-1f2ba67ef1218e86a26450d3201d309573c8eb9791114e458764c804ba8812173 |
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| cites | cdi_FETCH-LOGICAL-c312t-1f2ba67ef1218e86a26450d3201d309573c8eb9791114e458764c804ba8812173 |
| container_end_page | 797 |
| container_issue | 8 |
| container_start_page | 775 |
| container_title | Russian journal of genetics |
| container_volume | 50 |
| creator | Prozorov, A. A Fedorova, I. A Bekker, O. B Danilenko, V. N |
| description | The problem of Mycobacterium tuberculosis virulence, together with drug resistance, is becoming key for the design of drugs with a new mechanism of action and the production of modern concepts and tuberculosis treatment schemes. The review describes gene complexes and their products, including mycolic acids and global regulatory systems at the level of transcriptional, translational, and post-translational modification, etc. The criteria for selection of virulence/pathogenicity factors that might be used for comparative genomic analysis of strains differing in the degree of virulence were recommended. The experimental approaches and test systems for an adequate estimation of the virulence degree of different strains of M. tuberculosis were analyzed. |
| doi_str_mv | 10.1134/S1022795414080055 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1022-7954 |
| ispartof | Russian journal of genetics, 2014, Vol.50 (8), p.775-797 |
| issn | 1022-7954 1608-3369 |
| language | eng |
| recordid | cdi_crossref_primary_10_1134_S1022795414080055 |
| source | Springer Nature |
| subjects | acids Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine drug resistance genes genomics Human Genetics mechanism of action Microbial Genetics and Genomics Mycobacterium tuberculosis new drugs post-translational modification Reviews and Theoretical Articles selection criteria transcription (genetics) tuberculosis virulence |
| title | virulence factors of Mycobacterium tuberculosis: Genetic control, new conceptions |
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