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The Role of Serum Amyloid A1, Adhesion Molecules, Chemokines, and Chemokine Receptors Genes in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a multifactorial chronic inflammatory disease of the respiratory system. A key phenomenon of COPD pathogenesis is inflammation. The goal of the present study was to investigate the association of COPD with alleles and genotypes of the genes that encode...
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Published in: | Russian journal of genetics 2019, Vol.55 (1), p.105-113 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Chronic obstructive pulmonary disease (COPD) is a multifactorial chronic inflammatory disease of the respiratory system. A key phenomenon of COPD pathogenesis is inflammation. The goal of the present study was to investigate the association of COPD with alleles and genotypes of the genes that encode chemokines and chemokine receptors (
CCL11
,
CX3CR1
,
CCR5, CCL5
,
CXCL12
,
CCL2
, and
CCL17
), adhesion molecules (
PECAM1
and
ICAM1
), and serum amyloid A1 (
SAA1
). It was found that COPD was associated with the C allele and the TC genotype of
SAA1
(rs1136743C>T) (
P
= 0.0001,
OR
= 1.58 and
P
= 0.00001,
OR
 = 2.15, respectively); this association was confirmed in the subgroups differentiated by smoking status. Markers of COPD risk were also the CG genotype of
PECAM1
(rs281865545G>C) (
P
= 0.028,
OR
= 1.36) and the GG genotype of
ICAM1
(rs5498A>G), which were significantly associated with the disease in smokers (
P
= 0.005,
OR
= 1.66). The AA genotype of
CCL2
(rs1024611A>G) was associated with the disease in nonsmokers (
P
= 0.037,
OR
= 1.82). The GG genotype of
PECAM1
(rs281865545G>C) and the AA genotype of
CX3CR1
(rs3732378A>G) were associated with higher vital capacity (
P
= 0.014 and
P
= 0.04, respectively). Subjects with the GG genotype of
ICAM1
(rs5498A>G) exhibited lower forced expiration volume in 1 s and lower forced vital capacity (
P
= 0.025 and
P
= 0.029, respectively). |
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ISSN: | 1022-7954 1608-3369 |
DOI: | 10.1134/S1022795418120050 |