Mutations in the Insulin Signaling Pathway Genes Affect Carbohydrate Level under Heat Stress in Drosophila melanogaster Females

The effect of the following insulin signaling pathway genes on carbohydrate content under normal and heat stress conditions in Drosophila melanogaster females is studied: transcription factor Forkhead box class O ( dfoxo ) and insulin-like peptide DILP6 ( dilp6 ), which is synthesized in the fat bod...

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Bibliographic Details
Published in:Russian journal of genetics 2019-04, Vol.55 (4), p.519-521
Main Authors: Eremina, M. A., Karpova, E. K., Rauschenbach, I. Yu, Pirozhkova, D. S., Andreenkova, O. V., Gruntenko, N. E.
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Human Genetics
Microbial Genetics and Genomics
Short Communications
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Summary:The effect of the following insulin signaling pathway genes on carbohydrate content under normal and heat stress conditions in Drosophila melanogaster females is studied: transcription factor Forkhead box class O ( dfoxo ) and insulin-like peptide DILP6 ( dilp6 ), which is synthesized in the fat body. The hypomorphic mutations dilp6 41 and foxo BG01018 are shown to result in an increase in glucose and trehalose levels under normal conditions. For the first time, a sharp decline in the expression level of dilp6 and dfoxo genes caused by these mutations is demonstrated not to prevent the increase in the levels of both sugars under heat stress, but reduce the intensity of this response.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795419030050