The Role of Mitochondrial DNA Individuality in the Pathogenesis of Parkinson’s Disease

The present article reviews the rapidly growing body of research on the role of mitochondrial DNA (mtDNA) in the realization of individual risk of Parkinson’s disease. In this context, inherited mtDNA mutations, variants of its de novo polymorphism, haplogroup polymorphism, and accumulation of the m...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of genetics 2020-04, Vol.56 (4), p.402-409
Main Authors: Sukhorukov, V. S., Voronkova, A. S., Litvinova, N. A., Baranich, T. I., Illarioshkin, S. N.
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Human Genetics
Microbial Genetics and Genomics
Reviews and Theoretical Articles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present article reviews the rapidly growing body of research on the role of mitochondrial DNA (mtDNA) in the realization of individual risk of Parkinson’s disease. In this context, inherited mtDNA mutations, variants of its de novo polymorphism, haplogroup polymorphism, and accumulation of the mitochondrial genome somatic mutations are considered separately. Analysis of the reviewed published data shows that, at the moment, the haplogroup features and the mtDNA copy number should be considered the most proven risk factors for Parkinson’s disease. Data on similar importance of the mtDNA somatic mutations, its hereditary variants, and de novo mutations remain controversial and require careful study, primarily in animal and cell models.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795420040146