Pilot Study to Detect the Repertoires of T-Cell Receptor Gamma Chains in Patients with Juvenile Schizophrenia

Disfunction of the immune system and neuroinflammation may play a role in the pathogenesis of schizophrenia. The role of the adaptive immune system has to be elucidated. We present a pilot study to test the methodology of profiling immune repertoires of the TCR gamma chain by deep sequencing using s...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of genetics 2023-07, Vol.59 (7), p.739-743
Main Authors: Plotnikova, M. Yu, Patrikeev, A. D., Levchenko, A. Yu, Fedorenko, O. Yu, Andreeva, T. V., Rogaev, E. I.
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Human Genetics
Microbial Genetics and Genomics
Short Communications
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Disfunction of the immune system and neuroinflammation may play a role in the pathogenesis of schizophrenia. The role of the adaptive immune system has to be elucidated. We present a pilot study to test the methodology of profiling immune repertoires of the TCR gamma chain by deep sequencing using several patients with juvenile schizophrenia and unaffected control subjects. The clonotype profiles were revealed, and their diversity and presumable differences in the structure of the CDR3 TRG region of functional clones in juvenile schizophrenia and controls were assessed. This approach is promising for further comprehensive study of changes in the adaptive immune system in representative cohorts of patients with different forms of schizophrenia.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795423070086