A voltammetric method for the quantitative determination of midecamycin compared to its simultaneous HPLC determination

The aim of this study was to present the quantitative determination of midecamycin at a gold electrode in 0.05 M NaHCO 3 using cyclic linear sweep voltammetry. It was found that the value of the oxidative peak of pure midecamycin at 0.85 V vs. SCE at a scan rate of 50 mV s −1 is a linear function of...

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Bibliographic Details
Published in:Russian journal of electrochemistry 2011-07, Vol.47 (7), p.781-786
Main Authors: Drljević-Djurić, K. M., Avramov Ivić, M. L., Petrović, S. D., Mijin, D. Ž., Jadranin, M. B.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Electrochemistry
Physical Chemistry
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Summary:The aim of this study was to present the quantitative determination of midecamycin at a gold electrode in 0.05 M NaHCO 3 using cyclic linear sweep voltammetry. It was found that the value of the oxidative peak of pure midecamycin at 0.85 V vs. SCE at a scan rate of 50 mV s −1 is a linear function of the concentration in the range 0.1693–0.3289 mg cm −3 . The value of its reductive peak at 0.3 V vs. SCE is a linear function of the concentration in the range 0.11396–0.3802 mg cm −3 . HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the current peak values concerning the correlation with each investigated concentration of midecamycin. By MS spectrometry no degradation products were found in electrolyte during its quantitative determination.
ISSN:1023-1935
1608-3342
DOI:10.1134/S1023193511070056