Complexation of antibiotic levomycetin (Chloroamphenicol) with α-hederin and hederasaponin c under the conditions of electrospray ionization

The complexation of antibiotic levomycetin (chloroamphenicol) with triterpene glycoside α-hederin and hederasaponin C was investigated by electrospray ionization mass spectrometry. The glycosides form complexes with levomycetin in the molar ratio 1: 1. The molecular complex of α-hederin is more stab...

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Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2011-12, Vol.66 (14), p.1437-1440
Main Authors: Lekar’, A. V., Yakovishin, L. A., Borisenko, S. N., Vetrova, E. V., Borisenko, N. I.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
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Summary:The complexation of antibiotic levomycetin (chloroamphenicol) with triterpene glycoside α-hederin and hederasaponin C was investigated by electrospray ionization mass spectrometry. The glycosides form complexes with levomycetin in the molar ratio 1: 1. The molecular complex of α-hederin is more stable than the one of hederasaponin C because of the presence of a free carboxyl group in its aglycone fragment. The carboxyl group of hederasaponin C is involved into the formation of a glycosidic bond with the trisaccharide unit and is not available for complex formation.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934811140115