Evolutional principles of homology in regulatory genes of myogenesis

Analysis of early steps in muscular system development of invertebrates and vertebrates shows that early steps of myogenesis are regulated by genes-orthologs mainly belonging to two families, Pax and bHLH. In the majority of the following organisms, muscles formation (steps of determination and the...

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Bibliographic Details
Published in:Biology bulletin of the Russian Academy of Sciences 2012-07, Vol.39 (4), p.316-322
Main Authors: Ozernyuk, N. D, Myuge, N. S
Format: Article
Language:English
Subjects:
amphibians
Ascidiacea
basic helix-loop-helix transcription factors
Biochemistry
Biomedical and Life Sciences
birds
Caenorhabditis elegans
Cell Biology
Danio rerio
Developmental Biology
Drosophila melanogaster
Ecology
fish
gene activation
homeotic genes
insects
Life Sciences
mice
muscle development
muscles
rats
regulator genes
snails
Strongylocentrotus
Xenopus laevis
zinc finger motif
Zoology
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Summary:Analysis of early steps in muscular system development of invertebrates and vertebrates shows that early steps of myogenesis are regulated by genes-orthologs mainly belonging to two families, Pax and bHLH. In the majority of the following organisms, muscles formation (steps of determination and the earliest steps of myogenesis) is regulated by genes orthologs Pax3 which belong to the family Pax: nematodes (Caenorhabditis elegans, Pristionchus pacificus), insects (Drosophila melanogaster), echinoderms (Strongylocentrotus purpuratus), sea squirts (Ciona intestinalis, Holocynthia roretzi), fishes (Danio rerio), amphibians (Xenopus laevis), birds, and mammals (mouse, rat). The nematode C. elegans is an exception since formation of its muscles in this period is regulated by homeobox gene Pal-1 belonging to the family Caudal. The sea squirt C. intestinalis is also an exception because the earliest steps of development involved in further muscle formation are accompanied by activation of the gene CiSna (snail) (gene family basic Zinc finger). The next steps of myogenesis in all analyzed species are regulated by genes orthologs belonging to the family of transcriptional factors bHLH. They along with genes Pax3 are characterized by a high extent of homology in all studied groups of animals.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359012040085