Thymus development in early ontogeny: A comparative aspect

This review is dedicated to comparative analysis of the early stages of thymus ontogeny in fish, amphibians, and mammals. Morphological and molecular-genetic aspects of the formation of thymic stroma, colonization of this organ with T-cell progenitors, and interaction of different cell populations i...

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Bibliographic Details
Published in:Russian journal of developmental biology 2015-05, Vol.46 (3), p.111-120
Main Authors: Vasil’ev, K. A, Polevshchikov, A. V
Format: Article
Language:English
Subjects:
amphibians
Animal Anatomy
Biomedical and Life Sciences
Developmental Biology
early development
embryogenesis
fish
hematopoiesis
Histology
Life Sciences
mammals
Morphology
ontogeny
organogenesis
Reviews
stem cells
T-lymphocytes
thymus gland
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Summary:This review is dedicated to comparative analysis of the early stages of thymus ontogeny in fish, amphibians, and mammals. Morphological and molecular-genetic aspects of the formation of thymic stroma, colonization of this organ with T-cell progenitors, and interaction of different cell populations in the course of organogenesis are considered. Particular attention is given to the hematopoietic role of the thymus during embryogenesis and new data on the origin of T-cell progenitors. The hypothesis about the possible presence in the organ of a self-sustaining population of stem cells, formed regardless of fetal hematopoiesis areas, is discussed.
ISSN:1062-3604
1608-3326
DOI:10.1134/S106236041503008X