Novel alkyl cationic glycerolipids with a heterocyclic polar domain induce disturbances of the cell cycle and the death of human leukemia cells

A series of novel alkyl cationic glycerolipids with a heterocyclic polar domain have been synthesized. The most reactive compound, rac-N-{4-[(2-ethoxy-3-octadecyloxy)prop-1-yloxycarbonyl]butyl}-N′-ethylimidazolium iodide, at micromolar concentrations induced a delay of the cell cycle in the G1 phase...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2010-07, Vol.36 (4), p.532-534
Main Authors: Markova, A. A, Plyavnik, N. V, Tatarskii, V. V. Jr, Shtil, A. A, Serebrennikova, G. A
Format: Article
Language:English
Subjects:
alkyl cationic glycerolipids
apoptosis
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
cell cycle
Letters to the Editor
Life Sciences
Organic Chemistry
tumor cells
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Summary:A series of novel alkyl cationic glycerolipids with a heterocyclic polar domain have been synthesized. The most reactive compound, rac-N-{4-[(2-ethoxy-3-octadecyloxy)prop-1-yloxycarbonyl]butyl}-N′-ethylimidazolium iodide, at micromolar concentrations induced a delay of the cell cycle in the G1 phase, DNA fragmentation, and the apoptosis of human leukosis cells.
ISSN:1068-1620
1608-330X
DOI:10.1134/S106816201004014X