N-[4-(arylpiperazin-1-yl)butyl]bicyclo[2.2.1]hept-5-ene-endo-2,endo-3-dicarboximides and Their Epoxy Derivatives. Synthesis and affinity for 5-HT1a receptors

New ligands for 5-HT 1A serotonin receptors, N -[4-(4-arylpiperazin-1-yl)butyl]bicyclo[2.2.1]hept-5-ene- endo -2, endo -3-dicarboximides and their epoxy derivatives, were synthesized, and their affinity for 5-HT 1A receptors was estimated at 16.2 ± 2.0 to 0.60 ± 0.08 nM.

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Bibliographic Details
Published in:Russian journal of general chemistry 2009-02, Vol.79 (2), p.292-296
Main Authors: Makan, S. Yu, Tsymbal, D. I., Soboleva, S. G., Tarabara, I. N., Kas’yan, L. I., Andronati, S. A.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Summary:New ligands for 5-HT 1A serotonin receptors, N -[4-(4-arylpiperazin-1-yl)butyl]bicyclo[2.2.1]hept-5-ene- endo -2, endo -3-dicarboximides and their epoxy derivatives, were synthesized, and their affinity for 5-HT 1A receptors was estimated at 16.2 ± 2.0 to 0.60 ± 0.08 nM.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363209020212