Synthesis and mechanism of formation of 5-benzylidene-2-thioxo-2,3-dihydro-(1H,5H)-pyrimidine-4,6-diones difluoromethoxy derivatives

Reactions of 5-benzylidene-2-thioxo-2,3-dihydro-(1 H ,5 H )-pyrimidine-4,6-diones with a singlet difluorocarbene afford difluoromethoxy derivatives in 20–34% yield. The quantum-chemical analysis of the reaction mechanism showed that N,N -dimethylformamide is involved into the formation of difluorome...

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Bibliographic Details
Published in:Russian journal of general chemistry 2011-02, Vol.81 (2), p.415-419
Main Authors: Rakhimov, A. I., Kameneva, I. Yu, Avdeev, S. A., Fedunov, R. G.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Summary:Reactions of 5-benzylidene-2-thioxo-2,3-dihydro-(1 H ,5 H )-pyrimidine-4,6-diones with a singlet difluorocarbene afford difluoromethoxy derivatives in 20–34% yield. The quantum-chemical analysis of the reaction mechanism showed that N,N -dimethylformamide is involved into the formation of difluoromethoxy derivatives.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363211020228