Reaction with DNA and pharmacologic activity of 1,10-phenanthroline and electron-rich 1,10-phenanthrocyanine complexes of d-elements

Types of binding with DNA and pharmacologic activity of 1,10-phenanthroline and electron-rich 1,10-phenanthrocyanine complexes of d -elements are discussed. The relationship of the electronic and geometric structure of 1,10-phenanthroline complexes of transition metals to their interaction with DNA...

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Bibliographic Details
Published in:Russian journal of general chemistry 2012-03, Vol.82 (3), p.602-620
Main Authors: Demidov, V. N., Kas’yanenko, N. A., Antonov, V. S., Volkov, I. L., Sokolov, P. A., Pakhomova, T. B., Simanova, S. A.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Supplement: Rossiiskii Khimicheskii Zhurnal-Zhurnal Rossiiskogo Khimicheskogo Obshchestva im. D.I. Mendeleeva (Russian Chemistry Journal)
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Summary:Types of binding with DNA and pharmacologic activity of 1,10-phenanthroline and electron-rich 1,10-phenanthrocyanine complexes of d -elements are discussed. The relationship of the electronic and geometric structure of 1,10-phenanthroline complexes of transition metals to their interaction with DNA molecules is analyzed. The concept of redox-mediated antibacterial, antiviral, and antitumor activity of 1,10-phenanthroline complexes of d -elements is formulated.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363212030401