Targeted transport of low-sialylated recombinant human erythropoietin by polymer nanoparticles through the blood-brain barrier

The research on the nansomal forms s of low-sialylated recombinant human erythropoietin (ls-rhEPO) gave evidence for the efficiency of the nanotechnological approach to targeted delivery of this protein to the brain of experimental animals. Nanosomal ls-rhEPO formulations were found to exhibit neuro...

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Bibliographic Details
Published in:Russian journal of general chemistry 2013-12, Vol.83 (12), p.2571-2577
Main Authors: Balaban’yan, V. Yu, Ul’yanov, A. M., Elizarova, O. S., Solev, I. N., Litvinova, S. A., Garibova, T. L., Voronina, T. A.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Summary:The research on the nansomal forms s of low-sialylated recombinant human erythropoietin (ls-rhEPO) gave evidence for the efficiency of the nanotechnological approach to targeted delivery of this protein to the brain of experimental animals. Nanosomal ls-rhEPO formulations were found to exhibit neuroprotector activity. The established ability of the nanosomal formulations of ls-rhEPO to enhance BDNF and NGF gene expression in animal brain is to a great extent responsible for the mechanism of the neuroprotector action of this protein.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363213120566