Synthesis and antibacterial activity of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids N-(4-guanidylsulfonylphenyl)amides

Reaction of methyl aroylpyruvates with 4-aminobenzolsulfonylguanidine in acetic acid in the presence of anhydrous sodium acetate afforded N -(4-guanidylsulfonylphenyl)amides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids. Antibacterial activity of the synthesized compounds was studied.

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Published in:Russian journal of general chemistry 2015-04, Vol.85 (4), p.833-836
Main Authors: Gein, V. L., Bobrovskaya, O. V., Kovtonogova, I. V., Novikova, V. V.
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Language:English
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Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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description Reaction of methyl aroylpyruvates with 4-aminobenzolsulfonylguanidine in acetic acid in the presence of anhydrous sodium acetate afforded N -(4-guanidylsulfonylphenyl)amides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids. Antibacterial activity of the synthesized compounds was studied.
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Chemistry/Food Science
title Synthesis and antibacterial activity of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids N-(4-guanidylsulfonylphenyl)amides
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