Arylation of adamantanamines: II. Palladium-catalyzed amination of dihalobenzenes with adamantylalkanamines

Palladium-catalyzed arylation of various (1-adamantyl)alkanamines with isomeric (ortho, meta, and para) bromochloro- and dibromobenzenes was studied. Optimal catalytic systems were found for the synthesis of mono- and diamination products, and the dependences of their yields on the nature of the ini...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2010-12, Vol.46 (12), p.1790-1811
Main Authors: Averin, A. D, Ulanovskaya, M. A, Buryak, A. K, Savel'ev, E. N, Orlinson, B. S, Novakov, I. A, Beletskaya, I. P
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Summary:Palladium-catalyzed arylation of various (1-adamantyl)alkanamines with isomeric (ortho, meta, and para) bromochloro- and dibromobenzenes was studied. Optimal catalytic systems were found for the synthesis of mono- and diamination products, and the dependences of their yields on the nature of the initial amine and dihalobenzene and on the amount of base were examined. Side amination products were isolated, and paths of their formation were analyzed.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428010120055