Efficient tandem synthesis of 3-alkylaminoprop-2-enamides from 3-trimethylsilylprop-2-ynamides

A tandem synthetic approach to previously unknown 3-aminoprop-2-enamides has been developed. It is based on Si-C sp desilylation of 3-trimethylsilylprop-2-ynamides and subsequent addition of an amine to the triple bond of intermediate terminal propynamides. The effects of the reaction conditions and...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2013-06, Vol.49 (6), p.822-827
Main Authors: Andreev, M. V., Medvedeva, A. S., Safronova, L. P.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Review
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Summary:A tandem synthetic approach to previously unknown 3-aminoprop-2-enamides has been developed. It is based on Si-C sp desilylation of 3-trimethylsilylprop-2-ynamides and subsequent addition of an amine to the triple bond of intermediate terminal propynamides. The effects of the reaction conditions and amine nature on the efficiency of the process have been studied.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428013060031