Stereoselective synthesis of allylamines by iron-catalyzed cross-coupling of 3-chloroprop-2-en-1-amines with grignard reagents. Synthesis of naftifine

A general procedure for the synthesis of trans - and cis -allylamines has been developed on the basis of iron-catalyzed cross-coupling of Grignard reagents with stereochemically pure 3-chloroprop-2-en-1-amines prepared by allylation of amines with commercially available 1,3-dichloropropene isomers.

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Bibliographic Details
Published in:Russian journal of organic chemistry 2014-03, Vol.50 (3), p.322-331
Main Authors: Shakhmaev, R. N., Sunagatullina, A. Sh, Zorin, V. V.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Summary:A general procedure for the synthesis of trans - and cis -allylamines has been developed on the basis of iron-catalyzed cross-coupling of Grignard reagents with stereochemically pure 3-chloroprop-2-en-1-amines prepared by allylation of amines with commercially available 1,3-dichloropropene isomers.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428014030038