Synthesis and Biological Activity of Pyrazolo[1,5-c][1,3]benzoxazines Containing a Thiazolidin-4-one Fragment

5-[4-(2-Aryl-1,10b-dihydropyrazolo[1,5- c ][1,3]benzoxazin-5-yl)benzylidene]-1,3-thiazolidin-4-ones were synthesized by reactions of 4-[(3-R-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehydes with 2-(3-aryl-4,5-dihydro-1 H -pyrazol-5-yl)phenols and evaluated for antitumor and anti-inflammatory...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2020-04, Vol.56 (4), p.588-595
Main Authors: Horishny, V. Y., Mandzyuk, L. Z., Lytvyn, R. Z., Bodnarchuk, O. V., Matiychuk, V. S., Obushak, M. D.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Summary:5-[4-(2-Aryl-1,10b-dihydropyrazolo[1,5- c ][1,3]benzoxazin-5-yl)benzylidene]-1,3-thiazolidin-4-ones were synthesized by reactions of 4-[(3-R-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehydes with 2-(3-aryl-4,5-dihydro-1 H -pyrazol-5-yl)phenols and evaluated for antitumor and anti-inflammatory activities.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428020040053