The role of RNA metabolism in the pathogenesis of amyotrophic lateral sclerosis

Our review is focused on new aspects of the pathogenesis of amyotrophic lateral sclerosis (ALS); it considers the hypothesis that disturbances in transcription have a substantial role in ALS. We described the functions of ALS-related genes whose protein products are involved in various processes of...

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Bibliographic Details
Published in:Neurochemical journal 2012-07, Vol.6 (3), p.233-238
Main Authors: Lysogorskaia, E. V., Abramycheva, N. Yu, Illarioshkin, S. N., Zakharova, M. N.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Clinical Neurochemistry
Neurosciences
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Summary:Our review is focused on new aspects of the pathogenesis of amyotrophic lateral sclerosis (ALS); it considers the hypothesis that disturbances in transcription have a substantial role in ALS. We described the functions of ALS-related genes whose protein products are involved in various processes of mRNA metabolism. We present modern concepts on the functions of the DNA/RNA-binding proteins TDP43 and FUS which, according to many researchers, are key participants in the development of the neurodegenerative process.
ISSN:1819-7124
1819-7132
DOI:10.1134/S1819712412030099