Correlation between LOX-1 and CX3CR1 and Vascular Endothelial Function, Fibrinolytic Activity, and Recurrence after Thrombolysis in Patients with Cerebral Infarction

• Published in: Neurochemical journal 2022-12, Vol.16 (4), p.498-503
• Main Authors: Huo, X. L., Shao, J. H., Wang, L. S., Zhou, C. H., Ying, X. W., Jin, X. C.
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Clinical Neurochemistry; Neurosciences
• ISSN: 1819-7124; 1819-7132
• DOI: 10.1134/S1819712422040109

This study analyzed the relationship between LOX-1 and CX3CR1 and vascular endothelial function, fibrinolytic activity, and recurrence rate after thrombolysis in patients with cerebral infarction. Sixty patients with cerebral infarction who visited our hospital between May 2019 and April 2021 were enrolled as the study group, and 45 healthy individuals who underwent health checkups at our hospital during the same period were selected as the control group. The serum levels of LOX-1 and CX3CR1 in the study group were higher than those in the control group. The levels of serum LOX-1 and CX3CR1 were higher in the recurrence group than in the non-recurrence group. The study group had significantly lower plasma tPA and vWFp; higher plasma PAI-1; lower FMD levels; higher ba-PWV and ABI; and higher serum S100β, NSE, and NGF levels than those of the control group ( P < 0.05). Pearson correlation analysis showed that LOX-1 and CX3CR1 levels in patients with cerebral infarction were positively correlated with PAI-1, ba-PWV, ABI, S100β, NSE, and NGF ( r > 0, P < 0.05), and negatively correlated with tPA, vWF, and FMD ( r < 0, P < 0.05). Serum LOX-1 and CX3CR1 levels are closely related to endothelial function, fibrinolytic activity, and neurological function in patients with cerebral infarction, and their combined detection can effectively predict the occurrence of cerebral infarction and recurrence after thrombolysis, which can be used to identify high-risk groups.