Administration of Curcumin plus Treadmill Exercise Modulate Some Neuronal Enzyme Activities, Redox Markers and BDNF mRNA Expression in Pilocarpine-Induced Epileptic Seizure in Rats

Epilepsy, a chronic neurological illness, takes a heavy emotional toll on patients and their families. It is one of most neglected neurological illnesses in Africa. Studies have shown that epileptic seizures may be managed pharmacologically, behaviorally, and nutritionally. This study aims to invest...

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Bibliographic Details
Published in:Neurochemical journal 2023-09, Vol.17 (3), p.467-476
Main Authors: Ogunsuyi, O. B., Aro, P. O., Umar, H. I., Oboh, G.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Experimental Articles
Neurosciences
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Summary:Epilepsy, a chronic neurological illness, takes a heavy emotional toll on patients and their families. It is one of most neglected neurological illnesses in Africa. Studies have shown that epileptic seizures may be managed pharmacologically, behaviorally, and nutritionally. This study aims to investigate the therapeutic potential of combination of curcumin and aerobic exercise in treatment of epileptic seizure in rats. Four groups of Wistar strain albino rats; control, pilocarpine, pilocarpine + curcumin, and pilocarpine + curcumin + exercise was investigated to determine the effects of oral administration of curcumin and treadmill exercise on seizure frequency, activities of monoamine oxidase (MAO) and acetylcholinesterase (AChE), redox markers and Brain-Derived Neurotrophic Factor (BDNF) mRNA expression level in brain cortex and hippocampus of pilocarpine-induced epileptic rats. The results showed a significant reduction in the seizure frequency of rats treated with curcumin and curcumin + exercise groups, when compared with the pilocarpine-induced group. In addition, the significantly elevated MAO and AChE activities were ameliorated, coupled with a significant reduction in reactive oxygen species and thiol contents of the brain tissues of the pilocarpine-induced rats treated with curcumin plus exercise. Furthermore, the downregulated BDNF mRNA expression levels were significantly ameliorated in the induced groups treated with curcumin plus exercise. This study therefore, suggests that treadmill exercise could improve the therapeutic effects of curcumin in the management of epileptic seizure.
ISSN:1819-7124
1819-7132
DOI:10.1134/S1819712423030145