Study of surface heteroorganic antigens of rat hepatoma cells participating in the cell proliferation process

The study of the antigen diversion of cells of rat hepatocellular tumors, which is caused by the expression of normal antigens peculiar to renal definitive tissues (so-called “heteroorganic renal antigens”) is continued. Using an immune serum of narrow specificity, in the plasma membrane fractions o...

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Bibliographic Details
Published in:Cell and tissue biology 2008-06, Vol.2 (3), p.246-252
Main Authors: Teryukova, N. P., Blinova, G. I., Rozanov, Yu. M., Ivanov, V. A.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Cell Biology
Life Sciences
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Summary:The study of the antigen diversion of cells of rat hepatocellular tumors, which is caused by the expression of normal antigens peculiar to renal definitive tissues (so-called “heteroorganic renal antigens”) is continued. Using an immune serum of narrow specificity, in the plasma membrane fractions of Zajdela ascites hepatoma cells and of cultivated HTC hepatoma cells, heteroorganic antigens 110–115 and 125–130 kDa are revealed; the heteroorganic antigen 75–80 kDa is only detected for the Zajdela hepatoma cells. The participation of these heteroorganic antigens in the cell proliferation process is shown by the methods of radioisotope analysis and DNA flow cytometry.
ISSN:1990-519X
1990-5203
DOI:10.1134/S1990519X0803005X