Role of Transcription Factors FoxO3 and Myogenin in Regulation of E3 Ligases MuRF-1 and MAFbx Expression in Rat Soleus at an Early Stage of Disuse Atrophy

Hypokinesia and gravitational unloading lead to skeletal muscle atrophy resulting from alterations in the balance between anabolic and catabolic processes. Ubiquitin proteasome system plays a significant role in the process of protein breakdown in course of disuse atrophy. E3 ligases are essential c...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow). Supplement series A, Membrane and cell biology Membrane and cell biology, 2019, Vol.13 (1), p.36-39
Main Authors: Mochalova, E. P., Belova, S. P., Shenkman, B. S., Nemirovskaya, T. L.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Cell Biology
Life Sciences
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypokinesia and gravitational unloading lead to skeletal muscle atrophy resulting from alterations in the balance between anabolic and catabolic processes. Ubiquitin proteasome system plays a significant role in the process of protein breakdown in course of disuse atrophy. E3 ligases are essential components of this system. We analyzed changes in expression of E3 ligases MuRF-1 and MAFbx, as well as transcription factors FoxO3 and myogenin in rat soleus after 1 and 3 days of hindlimb unloading. We found that expression of E3 ligases was increased after 24 h of unloading, while phosphorylation of FoxO3 (S253) was decreased. However, the expression level of myogenin increased only 3 days after unloading. Our result suggests that earlier expression of MuRF-1 and MAFbx could be regulated by FoxO3, and that myogenin can also contribute to this process on the 3rd day of unloading
ISSN:1990-7478
1990-7494
DOI:10.1134/S1990747818040086