CLEC-2-Induced Signaling in Blood Platelets

— Platelet activating lectin-like receptor type C-2 (CLEC-2) has been identified on the platelet surface about a decade ago. The only known endogenous CLEC-2 agonist is podoplanin, a transmembrane protein expressed by lymphatic endothelial cells, lymph node fibroblastic reticular cells, kidney podoc...

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Bibliographic Details
Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2019, Vol.13 (1), p.26-35
Main Authors: Martyanov, A. A., Kaneva, V. N., Panteleev, M. A., Sveshnikova, A. N.
Format: Article
Language:English
Subjects:
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Medicinal Chemistry
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Summary:— Platelet activating lectin-like receptor type C-2 (CLEC-2) has been identified on the platelet surface about a decade ago. The only known endogenous CLEC-2 agonist is podoplanin, a transmembrane protein expressed by lymphatic endothelial cells, lymph node fibroblastic reticular cells, kidney podocytes, and by cells of certain tumors. CLEC-2 and podoplanin are involved in metastases, sepsis, development of deep-vein thrombosis. The CLEC-2 signaling cascade includes tyrosine kinases (Syk, SFK, Btk) as well as LAT adapter, and phospholipase Cγ2, which induces calcium signalling. CLEC-2, podoplanin and proteins, participating in the CLEC-2 signalling cascade, are considered as perspective targets for antithrombotic therapy.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750819010074