Structure and biological properties of sodium and potassium 1-(carboxy)-1-(N-methylamide)-2-(3′,5′-di-tert-butyl)-4-hydroxyphenyl)-propionates

• Published in: Russian journal of physical chemistry. B 2013-02, Vol.7 (1), p.44-49
• Main Authors: Volod’kin, A. A., Erokhin, V. N., Burlakova, E. B., Zaikov, G. E., Lomakin, S. M.
• Format: Article
• Language: English
• Subjects: Chemical Physics of Biological Processes; Chemistry; Chemistry and Materials Science; Physical Chemistry
• ISSN: 1990-7931; 1990-7923
• DOI: 10.1134/S1990793113010132

Sodium ( 1 ) and potassium ( 2 ) 1-(carboxy)-1-( N -methylamide)-2-(3′,5′-di- tert -butyl)-4-hydroxyphenyl)-propionates form crystal hydrates, which exist as both monomers and dimers. Quantum-chemical calculations in the PM6 approximation are used to determined the enthalpies of formation − H f po , thermal enthalpy H po , and entropy S po of the monomers and dimers, which are indicative of the possibility of existence of the dimers of propionates of alkali metals. The biological activity of these compounds in animal and plants is demonstrated to be dependent on their concentrations. Compounds 1 and 2 turned out to be efficient in the treatment of burn injuries, cancer, and radiation damage (in vivo and in vitro), as well as in promoting the growth of cereal plants.