Preparation and Physicochemical Properties of the Ecdysteroid-Containing Nanodispersions Based on the Triterpenoids from Birch Bark

The physicochemical parameters of spherical amorphous nanoparticles (SANPs), consisting of a mixture of triterpenoids of birch bark (MTB) with 20-hydroxyecdysone (20E), are studied. The nanoparticles are obtained by injection and investigated by electron microscopy, dynamic light scattering, and UV...

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Bibliographic Details
Published in:Nanotechnologies in Russia 2020, Vol.15 (1), p.37-44
Main Authors: Volodin, V. V., Quang, Nguyen Hong, Kaplun, A. P., Volodina, S. O.
Format: Article
Language:English
Subjects:
Bioorganic
Chemistry and Materials Science
Hybrid Nanomaterials
Industrial and Production Engineering
Machines
Manufacturing
Materials Science
Nanotechnology
Polymer
Processes
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Summary:The physicochemical parameters of spherical amorphous nanoparticles (SANPs), consisting of a mixture of triterpenoids of birch bark (MTB) with 20-hydroxyecdysone (20E), are studied. The nanoparticles are obtained by injection and investigated by electron microscopy, dynamic light scattering, and UV spectroscopy. In the studied series of concentrations of 20E from 5 to 20 wt %, in relation to the mass of the MTB, the optimal concentration is 20E 10 wt %; at this concentration, the most stable nanodispersions are formed in water, 20E is fully included in the SANPs, their average size is 193.1 nm, they are characterized by a narrow polydispersity interval, and they have the greatest absolute value of the ζ-potential. Ecdysteroid-containing SANPs of this composition can be recommended for use in medicine as prolonged forms of ecdysteroids as radioprotective and other pharmacological agents.
ISSN:1995-0780
1995-0799
DOI:10.1134/S1995078020010073