Genetic basis of predisposition to panic disorder

Panic disorder is a common, socially important human neurological disease. It is known that this disease has a strong genetic basis. Many laboratories investigate candidate genes involved in the control of pathological anxiety. This review summarizes the results of these studies and testify that the...

Full description

Saved in:
Bibliographic Details
Published in:Biology bulletin reviews 2012-07, Vol.2 (4), p.294-305
Main Authors: Korobeynikova, L. A., Rudko, O. I., Azimova, Yu. E., Fokina, N. M., Klimov, E. A.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell Biology
Ecology
Life Sciences
Zoology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Panic disorder is a common, socially important human neurological disease. It is known that this disease has a strong genetic basis. Many laboratories investigate candidate genes involved in the control of pathological anxiety. This review summarizes the results of these studies and testify that the development of a panic disorder is associated with the polymorphism of the genes of key neurotransmitter systems of the brain (serotonin, dopamine, cholecystokinin), as well as their metabolizing enzymes. Based on the available data, a complex approach is suggested to enable the identification a genotype that provides predisposition to panic disorder.
ISSN:2079-0864
2079-0872
DOI:10.1134/S2079086412040056