Brain Astrocytes and Synaptic Dissonance: Neurodegenerative and Mental Pathology

Experimental and clinical studies provided evidence that astrocytes are inherent components of neural networks. Astrocytes can affect synaptic processes by modulating the activity of neuro- and gliotransmitters. The role of the microglia in the organization of network spaces and the formation of neu...

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Bibliographic Details
Published in:Biology bulletin reviews 2020-11, Vol.10 (6), p.526-533
Main Author: Gomazkov, O. A.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell Biology
Ecology
Life Sciences
Zoology
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Summary:Experimental and clinical studies provided evidence that astrocytes are inherent components of neural networks. Astrocytes can affect synaptic processes by modulating the activity of neuro- and gliotransmitters. The role of the microglia in the organization of network spaces and the formation of neuroastrocytic domains is considered one of the leading mechanisms of memory and cognitive function. A disorder at the level of synaptic transmission results in the impairment of these processes. For the first time, we present the mechanism by which astrocytes, as components of synaptic processes, become involved in neuropsychic diseases.
ISSN:2079-0864
2079-0872
DOI:10.1134/S207908642006002X