Effect on bone anabolic markers of daily cheese intake with and without vitamin K 2 : a randomised clinical trial

Daily intake of 57 g Jarlsberg cheese has been shown to increase the total serum osteocalcin (tOC). Is this a general cheese effect or specific for Jarlsberg containing vitamin K and 1,4-dihydroxy-2naphtoic acid (DHNA)? 66 healthy female volunteers (HV) were recruited. By skewed randomisation (3:2),...

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Published in:BMJ nutrition, prevention & health prevention & health, 2022-12, Vol.5 (2), p.182-190
Main Authors: Lundberg, Helge Einar, Glasø, Morten, Chhura, Rahul, Shukla, Arjun Andre, Austlid, Torunn, Sarwar, Zohaib, Hovland, Kathrine, Iqbal, Sapna, Fagertun, Hans Erik, Holo, Helge, Larsen, Stig Einride
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Language:English
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Summary:Daily intake of 57 g Jarlsberg cheese has been shown to increase the total serum osteocalcin (tOC). Is this a general cheese effect or specific for Jarlsberg containing vitamin K and 1,4-dihydroxy-2naphtoic acid (DHNA)? 66 healthy female volunteers (HV) were recruited. By skewed randomisation (3:2), 41 HV were allocated to daily intake of 57 g Jarlsberg (J-group) and 25-50 g Camembert (C-group) in 6 weeks. After 6 weeks the C-group was switched to Jarlsberg. The study duration was 12 weeks with clinical investigations every 6 weeks. The main variables were procollagen type 1 N-terminal propeptide (PINP), tOC, carboxylated osteocalcin (cOC) and the osteocalcin ratio (R ) defined as the ratio between cOC and undercarboxylated osteocalcin (ucOC). Serum cross-linked C-telopeptide type I collagen (CTX), vitamin K , lipids and clinical chemistry were used as secondary variables. PINP, tOC, cOC, R and vitamin K increased significantly (p
ISSN:2516-5542
2516-5542
DOI:10.1136/bmjnph-2022-000424