Effects of ileocolonic delivered vitamin B 2 , B 3 and C (ColoVit) or the Groningen anti-inflammatory diet on disease course and microbiome of patients with Crohn's disease (VITA-GrAID study): a protocol for a randomised and partially blinded trial

Diet plays a pivotal role in the onset and progression of Crohn's disease (CD). Nutritional interventions revealed effects on intestinal inflammation and gut microbial composition. However, data from well-designed and controlled dietary trials are lacking. Therefore, evidence-based dietary reco...

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Bibliographic Details
Published in:BMJ open 2023-03, Vol.13 (3), p.e069654
Main Authors: Otten, Antonius Timotheus, Peters, V, Barth, I, Stevens, C L, Bourgonje, A R, Frijlink, H W, Harmsen, H J M, Rehman, A, Campmans-Kuijpers, M J E, Dijkstra, G
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents
Crohn Disease - drug therapy
Diet
Humans
Microbiota
Multicenter Studies as Topic
Randomized Controlled Trials as Topic
Vitamins
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Summary:Diet plays a pivotal role in the onset and progression of Crohn's disease (CD). Nutritional interventions revealed effects on intestinal inflammation and gut microbial composition. However, data from well-designed and controlled dietary trials are lacking. Therefore, evidence-based dietary recommendations are still unavailable to patients and physicians. Here, we aim to investigate the effects of an evidence-based anti-inflammatory diet, and an ileocolonic-targeted capsule containing vitamin B , B and C (ColoVit) on patients with CD and their healthy household members. In this multicentre, randomised, placebo-controlled, partially blinded nutritional intervention trial, we aim to recruit 255 CD patients with Harvey-Bradshaw Index
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2022-069654