Glycemic and urinary volume responses in diabetic mellitus rats treated with Solanum lycocarpum

• Published in: Applied physiology, nutrition, and metabolism nutrition, and metabolism, 2010-02, Vol.35 (1), p.40-44
• Main Authors: Farina, Fabiane, Piassi, Flávia Grillo, Moysés, Margareth Ribeiro, Bazzolli, Denise Mara Soares, Bissoli, Nazaré de Souza
• Format: Article
• Language: English
• Subjects: alloxan; alloxane; Analysis of Variance; Animals; Biological and medical sciences; Blood Glucose - drug effects; Body Mass Index; Carbohydrates; Cardiomegaly - pathology; Care and treatment; Control; Diabetes; diabetes mellitus; Diabetes Mellitus - blood; Diabetes Mellitus - diet therapy; Diabetes Mellitus - urine; diabète sucré; Disease Models, Animal; Drinking - drug effects; Eating - drug effects; Fiber in human nutrition; fibers; fibres; Fundamental and applied biological sciences. Psychology; Glucose; Glycemic Index - drug effects; Hyperglycemia; hyperglycémie; Hypertrophy - pathology; Kidney - drug effects; Kidney - pathology; Male; Nutritional aspects; Organ Size - drug effects; Physiological aspects; Rats; Rats, Wistar; Rodents; Sodium - urine; Solanum; Solanum lycocarpum; Urine; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
• ISSN: 1715-5312; 1715-5320
• DOI: 10.1139/H09-131

Dietary fiber performs important functions in diabetes mellitus control and treatment. In this study, we evaluate the reduction in plasma glucose after the treatment of diabetic rats with high-fiber Solanum lycocarpum flour. We found that serum glucose, water and food intake, urine excretion, and urine sodium concentration were reduced in S. lycocarpum flour-treated diabetic rats (TDRs), compared with diabetic control rats (DCRs). In addition, TDRs did not show signs of kidney hypertrophy, unlike those in the DCR group. These results suggest that the use of S. lycocarpum flour can be an effective support in diabetes mellitus treatment.