Synthesis of 2,6-Naphthyridine, 4-Methyl-2,6-naphthyridine, and their Derivatives

A detailed outline of the experimental procedures for the synthesis of 2,6-naphthyridine and 4-methyl-2,6-naphthyridine is given. Cyclization of 2-(4-cyano-3-pyridyl)propionitrile with anhydrous hydrogen bromide lead to 3-amino-4-methyl-2,6-naphthyridine which was transformed into 4-methyl-2,6-napht...

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Bibliographic Details
Published in:Canadian journal of chemistry 1974-03, Vol.52 (5), p.843-848
Main Authors: Taurins, Alfred, Li, Rosita Tan
Format: Article
Language:English
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Summary:A detailed outline of the experimental procedures for the synthesis of 2,6-naphthyridine and 4-methyl-2,6-naphthyridine is given. Cyclization of 2-(4-cyano-3-pyridyl)propionitrile with anhydrous hydrogen bromide lead to 3-amino-4-methyl-2,6-naphthyridine which was transformed into 4-methyl-2,6-naphthyridine in a series of reactions. The u.v. spectra of 2,6- and 4-methyl-2,6-naphthyridine and their amino and halogen derivatives were recorded.
ISSN:0008-4042
1480-3291
DOI:10.1139/v74-133