Which Brain Regions are Important for Seizure Dynamics in Epileptic Networks? Influence of Link Identification and EEG Recording Montage on Node Centralities

Nodes in large-scale epileptic networks that are crucial for seizure facilitation and termination can be regarded as potential targets for individualized focal therapies. Graph-theoretical approaches based on centrality concepts can help to identify such important nodes, however, they may be influen...

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Bibliographic Details
Published in:International journal of neural systems 2017-02, Vol.27 (1), p.1650033
Main Authors: Geier, Christian, Lehnertz, Klaus
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Algorithms
Brain
Brain - physiopathology
Brain - surgery
Brain Mapping - methods
Child
Convulsions & seizures
Drug Resistant Epilepsy - physiopathology
Drug Resistant Epilepsy - surgery
Electrocorticography - methods
Electroencephalography
Epilepsies, Partial - physiopathology
Epilepsies, Partial - surgery
Epilepsy
Female
Humans
Male
Middle Aged
Networks
Neural Pathways - physiopathology
Neural Pathways - surgery
Nodes
Recording
Seizing
Seizures
Seizures - physiopathology
Seizures - surgery
Time Factors
Young Adult
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Summary:Nodes in large-scale epileptic networks that are crucial for seizure facilitation and termination can be regarded as potential targets for individualized focal therapies. Graph-theoretical approaches based on centrality concepts can help to identify such important nodes, however, they may be influenced by the way networks are derived from empirical data. Here we investigate evolving functional epileptic brain networks during 82 focal seizures with different anatomical onset locations that we derive from multichannel intracranial electroencephalographic recordings from 51 patients. We demonstrate how the various methodological steps (from the recording montage via node and link inference to the assessment of node centralities) affect importance estimation and discuss their impact on the interpretability of findings in the context of pathophysiological aspects of seizure dynamics.
ISSN:0129-0657
1793-6462
DOI:10.1142/S0129065716500337