Carbohydrate-Protein Interactions in Vascular Biology

Carbohydrate-protein interactions participate in a wide variety of biological and pathological events. In recent years, particular attention has been paid to the carbohydrate-protein interactions that occur in vascular biology. Sialylated oligosaccharides are ligands of a structurally diverse group...

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Bibliographic Details
Published in:Annual review of cell and developmental biology 1995-01, Vol.11 (1), p.601-631
Main Authors: Nelson, R M, Venot, A, Bevilacqua, M P, Linhardt, R J, Stamenkovic, I
Format: Article
Language:English
Subjects:
Animals
Antigens, CD - metabolism
Antigens, Differentiation, B-Lymphocyte - metabolism
Blood Vessels - physiology
Carbohydrate Conformation
Carbohydrate Metabolism
Carbohydrate Sequence
Cell Adhesion Molecules
Glycoproteins - metabolism
Glycosaminoglycans - metabolism
Heparin - metabolism
Heparitin Sulfate - metabolism
Humans
Hyaluronic Acid - metabolism
Lectins - metabolism
Mammals
Membrane Glycoproteins - metabolism
Molecular Sequence Data
Proteins - metabolism
Receptors, Immunologic - metabolism
Selectins - metabolism
Sialic Acid Binding Ig-like Lectin 1
Sialic Acid Binding Ig-like Lectin 2
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Summary:Carbohydrate-protein interactions participate in a wide variety of biological and pathological events. In recent years, particular attention has been paid to the carbohydrate-protein interactions that occur in vascular biology. Sialylated oligosaccharides are ligands of a structurally diverse group of proteins that include the selectins and members of the immunoglobulin superfamily. Various glycosaminoglycans can be recognized by an overlapping set of proteins that include two of the selectins and CD44. Emerging knowledge of carbohydrate-protein interactions in human pathophysiology are discussed.
ISSN:1081-0706
1530-8995
DOI:10.1146/annurev.cb.11.110195.003125