Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals

In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of cell and developmental biology 2016-10, Vol.32 (1), p.649-675
Main Authors: Ramasamy, Saravana K, Kusumbe, Anjali P, Itkin, Tomer, Gur-Cohen, Shiri, Lapidot, Tsvee, Adams, Ralf H
Format: Article
Language:English
Subjects:
angiocrine factors
Animals
Blood Vessels - metabolism
bone angiogenesis
Bone Marrow - blood supply
Endothelial Cells - metabolism
Hematopoiesis
hematopoietic stem cells
Humans
Osteogenesis
Signal Transduction
vascular niche
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.
ISSN:1081-0706
1530-8995
DOI:10.1146/annurev-cellbio-111315-124936