MOLECULAR MECHANISMS OF EPITHELIAL MORPHOGENESIS

Epithelial morphogenesis comprises the various processes by which epithelia contribute to organ formation and body shape. These complex and diverse events play a central role in animal development and regeneration. Recently, the characterization of some of the molecular mechanisms involved in epithe...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of cell and developmental biology 2002-01, Vol.18 (1), p.463-493
Main Authors: Schöck, Frieder, Perrimon, Norbert
Format: Article
Language:English
Subjects:
Animals
Body Patterning - physiology
cadherin
Cell Adhesion - physiology
Cell Communication - physiology
Cell Differentiation - physiology
Cytoskeleton - metabolism
Cytoskeleton - ultrastructure
Drosophila
Epithelial Cells - cytology
Epithelial Cells - metabolism
Epithelium - embryology
Epithelium - growth & development
Epithelium - metabolism
Extracellular Matrix - metabolism
GTPase
Humans
integrin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epithelial morphogenesis comprises the various processes by which epithelia contribute to organ formation and body shape. These complex and diverse events play a central role in animal development and regeneration. Recently, the characterization of some of the molecular mechanisms involved in epithelial morphogenesis has provided an abundance of new information on the role and regulation of the cytoskeleton, cell-cell adhesion, and cell-matrix adhesion in these processes. In this review, we discuss our current understanding of the molecular mechanisms driving cell shape changes, cell intercalation, fusion of epithelia, ingression, egression, and cell migration. Our discussion is mostly focused on results from Drosophila and mammalian tissue culture but also draws on the insights gained from other organisms.
ISSN:1081-0706
1530-8995
DOI:10.1146/annurev.cellbio.18.022602.131838