Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin

Microneedle patches (MNPs) contain arrays of solid needles measuring hundreds of microns in length that deliver drugs and vaccines into skin in a painless, easy-to-use manner. Optimal MNP design balances multiple interdependent parameters that determine mechanical strength, skin-insertion reliabilit...

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Bibliographic Details
Published in:Annual review of chemical and biomolecular engineering 2017-06, Vol.8 (1), p.177-200
Main Author: Prausnitz, Mark R
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Drug Delivery Systems - instrumentation
Equipment Design
Humans
microarray patch
microfabricated microdevice
microneedle patch
Needles
Pharmaceutical Preparations - administration & dosage
pharmaceutical product commercialization
Skin - metabolism
skin vaccination
transdermal drug delivery
Transdermal Patch
Vaccination - instrumentation
Vaccines - administration & dosage
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Summary:Microneedle patches (MNPs) contain arrays of solid needles measuring hundreds of microns in length that deliver drugs and vaccines into skin in a painless, easy-to-use manner. Optimal MNP design balances multiple interdependent parameters that determine mechanical strength, skin-insertion reliability, drug delivery efficiency, painlessness, manufacturability, and other features of MNPs that affect their performance. MNPs can be made by adapting various microfabrication technologies for delivery of small-molecule drugs, biologics, and vaccines targeted to the skin, which can have pharmacokinetic and immunologic advantages. A small number of human clinical trials, as well as a large and growing market for MNP products for cosmetics, indicate that MNPs can be used safely, efficaciously, and with strong patient acceptance. More advanced clinical trials and commercial-scale manufacturing will facilitate development of MNPs to realize their potential to dramatically increase patient access to otherwise-injectable drugs and to improve drug performance via skin delivery.
ISSN:1947-5438
1947-5446
DOI:10.1146/annurev-chembioeng-060816-101514