Resistance to Avermectins: Extent, Mechanisms, and Management Implications

The avermectins represent a group of natural compounds with potent pesticidal activities. Because of their novel mode of action, they represent an important resource for pest control and resistance management. In the Colorado potato beetle, the house fly, and the two-spotted spider mite, resistance...

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Bibliographic Details
Published in:Annual review of entomology 1995-01, Vol.40 (1), p.1-30
Main Authors: Clark, J K, Scott, J G, Campos, F, Bloomquist, J R
Format: Article
Language:English
Subjects:
Acari
Animals
AVERMECTINAS
AVERMECTINE
AVERMECTINS
Chrysomelidae
Coleoptera
CROSS RESISTANCE
DESINTOXICACION
DETOXIFICATION
Diptera
Houseflies
Insect Control
INSECT PESTS
INSECTE NUISIBLE
INSECTICIDAS
INSECTICIDE
Insecticide Resistance
INSECTICIDES
INSECTOS DANINOS
Ivermectin - analogs & derivatives
LEPTINOTARSA DECEMLINEATA
METABOLISM
METABOLISME
METABOLISMO
Mites
MUSCA DOMESTICA
Muscidae
PEST INSECTS
RESISTANCE AUX PRODUITS CHIMIQUES
RESISTANCE TO CHEMICALS
RESISTENCIA A PRODUCTOS QUIMICOS
REVIEWS
Tetranychidae
TETRANYCHUS URTICAE
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Summary:The avermectins represent a group of natural compounds with potent pesticidal activities. Because of their novel mode of action, they represent an important resource for pest control and resistance management. In the Colorado potato beetle, the house fly, and the two-spotted spider mite, resistance to abamectin is usually autosomal, recessive, and polygenic. Although these aspects are beneficial in resistance management, the fact that resistance could be readily selected for suggests that abamectin needs to be used in moderation. Furthermore, several major resistance mechanisms (e.g. excretion, oxidative metabolism, penetration) and minor factors (e.g. altered target site, conjugation, hydrolysis/sequestration) have been implicated in abamectin resistance. Thus, the question is not whether resistance to abamectin will occur but is simply when and how it will occur. To address this problem, we have gathered information on the genetics, biochemical mechanisms, effectiveness of synergists, and cross-resistances to other insecticides from three abamectin-resistant insects. Judicious implementation of this information may prove useful in the resistance management of this natural pesticide.
ISSN:0066-4170
1545-4487
DOI:10.1146/annurev.en.40.010195.000245